Gut immune system and oral tolerance

Gut immune system and oral tolerance.

Gut mucosal surfaces separate the external environment from the internal sterile environment and so represent a first line of defence system. This barrier faces environments rich in pathogens that have developed effective mechanisms for colonisation of epithelial surfaces and invasion of mucosal tissues, but also harmless antigens such as food, airborne antigens or commensal bacterial flora. Th...

Immunology of the gut and oral tolerance

The gastrointestinal tract has developed a unique immunological system because of its close proximity to the intestinal contents. The system has evolved in such a way that it does not respond to the presence of beneficial microbes, but retains the ability to react quickly to the presence of harmful organisms. The challenge faced by the mucosal immune system is to generate an immune response of ...

The gut and oral glucose tolerance.

Oral immune therapy: targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease

Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs. Oral immune therapy is a method of systemic immune modulation via alteration of the gut immune system. It uses the inherit ability of the innate system of the gut to redirect the systemic innate and adaptive immune responses. Oral immune ...

big bang gene modulates gut immune tolerance in Drosophila.

Chronic inflammation of the intestine is detrimental to mammals. Similarly, constant activation of the immune response in the gut by the endogenous flora is suspected to be harmful to Drosophila. Therefore, the innate immune response in the gut of Drosophila melanogaster is tightly balanced to simultaneously prevent infections by pathogenic microorganisms and tolerate the endogenous flora. Here...